Chemistry

Supramolecular Synthons in Crystal Engineering of Pharmaceutical Properties

Ashwini Kumar Nangia

Concepts of Inorganic Chemistry

Mamta Kharkwal, S. B. Tyagi

Inorganic chemistry is an important branch of chemistry that impacts both our daily routine and several technological and scientific disciplines. The aim of this book is to incorporate the new advancements and developments in this field of study and to discuss their significance in our lives. A detailed discussion about the various aspects of inorganic chemistry is presented and the interpretation of structures, bonding, and reactivity of inorganic substances is also explored. Print edition not for sale in South Asia (India, Sri Lanka, Nepal, Bangladesh, Pakistan or Bhutan)

Green Chemistry in 21st Century and Beyond

V.K. Ahluwalia, Sunita Dhingra

With an emphasis on minimizing the use and generation of hazardous substances, Green Chemistry is a significant branch of Chemical Engineering. This book details the fundamentals associated with this field of study and focuses on designing products through renewable starting materials, recyclable chemicals, and benign synthesis. The use of green solvents, organic transformations, catalysts, and electrochemical synthesis are also discussed. The subject matter of this book also Twelve Principles of Green Chemistry Baylis-Hillman Reaction Perfluorinated Catalysts Microwave assisted Organic Transformations in Water Reformatsky Reaction This book is aimed at Engineering students, chemists working in the R&D sector, and undergraduate and postgraduate scholars. Print edition not for sale in South Asia (India, Sri Lanka, Nepal, Bangladesh, Pakistan or Bhutan)

General Analytical Chemistry

Jean-Louis Burgot

This book is devoted to the quantitative electrochemical methods of analysis in solution. A theoretical knowledge of each method is discussed. The methods are illustrated with several examples covering a wide range of types of analysis. The book is divided in three parts. The first one is introductory. It recalls some definitions and some basic concepts of electrochemistry. The second part describes the methods themselves. Are studied voltametric methods, amperometry, potentiometry, conductometry, the electrogravimetry and coulometry. Some chapters are also dedicated to the chemical and electrochemical sensors. The third part consists in a supplementary theoretical knowledge of each method.

Oxadiazole in Material and Medicinal Chemistry

Priya Ranjan Sahoo, Abhishek Saxena, Satish Kumar

The book “Oxadiazole in Material and Medicinal Chemistry” is based on the utility of organic motifs that contain oxadiazole units in their molecular architecture. Most of the common and alternate ways to synthesize oxadiazole-based probes have been discussed. The book also features some of the advanced applications of such organic motifs in liquid crystals, OLEDs, imaging agents, and medicines. Few practical applications of oxadiazole-based molecules in material and electronic areas have also been outlined. The book focuses on understanding the role of oxadiazole scaffolds in biological events, disease monitoring, and detection. The therapeutic effect of oxadiazole-based probes on cancer, inflammation, and neurodegeneration have also been covered in the book. Oxadiazole probes in inhibitor design and the corresponding inhibitory potency as drug development have been outlined. The authors hope that the book will garner positive interest among students and researchers associated with material and medicinal chemistry.

Polyampholytes in Advanced Polymer Science and Emerging Technologies

Sarkyt E. Kudaibergenov

Maths in Chemistry: Numerical Methods for Physical and Analytical Chemistry

Prerna Bansal

Click Chemistry

Ram K. Gupta

Click chemistry involves highly efficient, reliable, and stereoselective reactions that can synthesize new materials cost-effectively. The first volume entitled “Click Fundamentals and Synthesis” covers the fundamentals, mechanisms, kinetics, and various approaches to synthesizing new materials making it suitable for synthetic chemists and researchers working in nanoscience and technology. The main objective of this book is to provide information about current, state-of-the-art development in click chemistry as well as challenges. Experts from around the world have contributed towards this book, making this a suitable textbook for students and providing new guidelines to researchers and industries working in these areas.

Advances in Chromatography: Volume 60

Nelu Grinberg, Peter W. Carr

Chemistry and Pharmacology of Drug Discovery

Jie Jack Li

Case studies of 20 successful FDA-approved drugs, from biological rationale to clinical efficacy studies and state-of-the-art applications Chemistry and Pharmacology of Drug Discovery illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines, discussing a total of 20 drugs that are all FDA-approved post 2021—some of which are first-in-class and revolutionary. The four sections in this book cover Infectious Disease, Cancer Drugs, CNS Drugs, and Miscellaneous Drugs. Each chapter covers background material on the drug class and/or disease indication and key aspects relevant to the discovery of the drug, including structure-activity relationships, pharmacokinetics, drug metabolism, efficacy, and safety. This book is contributed to by various veterans and well-known experts in medical chemistry, many of whom discovered the drugs they reviewed, leading to tremendous quality and depth of insight. Some of the drugs covered in Chemistry and Pharmacology of Drug Discovery Nirmatrelvir (Paxlovid with Ritonavir), a 3-chymotrypsin-like protease inhibitor for treating SARS-CoV-2 infectionDoravirine (Pifeltro), a third-generation non-nucleoside reverse transcriptase inhibitor for the treatment of HIV-1 infectionOteseconazole (Vivjoa), a CYP51 inhibitor for treating recurrent vulvovaginal candidiasis, and Rimegepant (Nurtec ODT), a CGRP antagonist for treating migraineCiprofol (Cipepofol), a γ-Aminobutyric acid receptor agonist for induction of anesthesia, and Ozanimod (Zeposia), an S1P receptor antagonist for treating multiple sclerosisDeucravacitinib (Sotyktu), a first-in-class deuterated TYK2 inhibitor for the treatment of plaque psoriasis Chemistry and Pharmacology of Drug Discovery serves as an excellent and highly authoritative learning resource for medicinal, organic, synthetic, and process chemists as well as research scientists in lead optimization and process development.

Advances in Natural Polymers: Extraction Methods and Applications

Cornelia Vasile, Gabriel Aguirre-Álvarez, Xiao-Feng Sun

S-Heterocycles: Synthesis and Biological Evaluation

Keshav Lalit Ameta

This book presents the recent research on sulfur-containing heterocyclic scaffolds that are crucial for biological processes. The numerous synthetic techniques utilized for the design and synthesis of different sized S-heterocycles, particularly biologically active frameworks with their pharmacological significance, are discussed in this book. This book is a useful reference for students, researchers and professionals working in the chemical and pharmaceutical industries.

Advanced Experimental Inorganic Chemistry

V.K. Ahluwalia, Sunita Dhingra

This book is divided into four - Part I deals with Qualitative Inorganic Analysis. Systematic procedures of anion and cation analysis alongwith their confirmatory tests and spot tests are given. Detection of cations by flame photometry and atomic absorption spectroscopy are also incorporated. Besides chromatographic separation and identification of cations are also discussed. - Part II deals with volumetric analysis. The instrumental methods of volumetric analysis have also been incorporated. - Part III deals with gravimetric analysis. Estimation of one or more than one constituent in a solution and instrumental methods of quantitative analysis are also incorporated. - Part IV describes many inorganic preparations. These include simple salts, double salts, complex salts, amalgams, activated metals, organometallics and some other miscellaneous inorganic preparations. The uses of various compounds have also been mentioned. Print edition not for sale in South Asia (India, Sri Lanka, Nepal, Bangladesh, Pakistan or Bhutan)

Polymer Supported Organic Catalysts

Narendra Chauhan, Sapana Jadoun

Polymer-supported organic catalysts are largely insoluble in most reaction solvents, which allows for easy recovery and recycling of the catalysts. They are generally stable, readily available, and environmental friendly, so they have attracted the interest of many synthetic chemists in the industrial and academic fields. In this book, different types of polymer-supported catalysts based on peptides, polystyrene, polyethers, poly(acrylic acid), poly(ethylene imine), poly(2-oxazoline), poly(isobutylene), poly(norbornene), etc., as well as metals are included with their synthetic organic synthesis applications. It is believed that this work will be of interest to organic chemists, material scientists, chemical engineers, polymer scientists and technologists.

Ludwig's Applied Process Design for Chemical and Petrochemical Plants Incorporating Process Safety Incidents: Volume 1B

A. Kayode Coker

Ludwig's Applied Process Design for Chemical and Petrochemical Plants Incorporating Process Safety Incidents: Volume 1A

A. Kayode Coker

Ludwig's Applied Process Design for Chemical and Petrochemical Plants is ever evolving starting with the first edition some 60 years ago. The volumes in this fifth edition provide improved techniques and fundamental designs methodologies to guide the practicing engineer in designing process equipment and applying chemical processes to the properly detailed hardware. Like its predecessor, this new edition continues to present updated information for achieving optimum operational and process conditions and to avoid problems caused by inadequate sizing and lack of internally detailed hardware. The volumes provide both fundamental theories where applicable and direct application of these theories to applied equations essential in the design effort. This approach in presenting design information is essential for troubleshooting process equipment and in executing system performance analysis. Volume 1 covers process planning, flow-sheeting and scheduling, cost estimation and economic, physical properties of liquids and gases, fluid flow, mixing of liquids, mechanical separations, process safety and pressure-relieving devices, metallurgy and corrosion, process optimization. It builds upon Ernest E. Ludwig's classic text to further enhance its use as a chemical engineering process design manual of methods and proven fundamentals. This new edition includes new content on three-phase separation, mixing of liquids, ejectors and mechanical vacuum systems, process safety and pressure-relieving devices, metallurgy and corrosion, process safety management / HAZOP and hazard analyses, and optimization of chemical process / blending.

Nanometal Catalysis in Organic Synthesis

Ming Bao, Jiasheng Wang, Xiujuan Feng, Jingjie Luo, Jian Sun

Click Chemistry

Vinod K. Tiwari, Manoj K. Jaiswal, Sanchayita Rajkhowa, Sumit K. Singh

This book comprehensively covers the fundamentals and latest advancements in the area of click chemistry. It discusses notable applications of click chemistry in various emerging areas ranging from chemical biology to catalysis and from medicinal chemistry to material sciences. Various topics covered in this book are catalysis in regioselectivity in click chemistry, organocatalysis in triazole synthesis, Bertozzi’s Bioorthogonal Concept, photo-triggered click chemistry, SuFFEx Click, Thiol-Ene Click, MCR Click, Intramolecular Click Chemistry, synthesis of diverse triazoles and their applications, Click's Post Functionalization, etc. The book is a valuable reference for beginners, researchers and professionals interested in sustainable click concept and its diverse applications in allied fields.

Introduction to Multivariate Calibration: A Practical Approach

Alejandro C. Olivieri

This book offers an introductory-level guide to the complex field of multivariate analytical calibration, with particular emphasis on real applications such as near infrared spectroscopy. It presents intuitive descriptions of mathematical and statistical concepts, illustrated with a wealth of figures and diagrams, and consistently highlights physicochemical interpretation rather than mathematical issues. In addition, it describes an easy-to-use and freely available graphical interface, together with a variety of appropriate examples and exercises. Lastly, it discusses recent advances in the field (figures of merit, detection limit, non-linear calibration, method comparison), together with modern literature references.

Catalysis for Fine Chemicals

Werner Bonrath

The Polyhedral Face of Coordination Chemistry

Antonio Bianchi Bianchi, Matteo Savastano Savastano

Metallocenes in Regio- and Stereoselective Synthesis

Marko Hapke, Martin Kotora

Modern Natural Product Synthesis: Overcoming Difficulties

Masahisa Nakada, Keiji Tanino, Kazuo Nagasawa, Satoshi Yokoshima

Organic Chemistry

Jeffrey John Deakin

Industrial Inorganic Chemistry

Mark Anthony Benvenuto

Synthesis of Medium-Sized Cycloalkenes via Fused-Cyclobutenes

Tomohiro Ito

This book explains the existence of the intermediate using two computational chemistry and coordination chemistry. In this book, the author has developed new methods for synthesizing medium-sized cycloalkenes by utilizing the 4π-electrocyclic reaction of fused-cyclobutenes. The fundamental and most important strategy and feature of the work are as first, cyclobutene is used as a readily available raw material with high-strain energy to generate more strained medium-sized cis,trans-cycloalkadiene molecules. Second, by judiciously selecting the reaction conditions, the short-lived intermediate (medium-sized cis,trans-cycloalkadiene) can be converted to medium-sized cis- or trans-cycloalkenes. For the former, the generation of the medium-sized cis,trans-cycloalkadiene intermediate is greatly affected by the substituent on the cyclobutene, and there are few examples of its generation confirmed at room temperature. Regarding the latter, the synthesis of trans-cycloalkenes is noteworthy in terms of establishing a new synthetic methodology and providing one of the few asymmetric synthesis methods, which has not been achieved before. Readers of this book can gain novel insights into strained molecules involved not only in small-sized cycloalkenes but also in medium-sized ones.

Photochemical and Electrochemical Activation Strategies of C(sp3)-Based Building Blocks for Organic Synthesis

Su Yong Go

This book addresses novel C(sp3)-C(sp2) and C(sp3)-heteroatom bond-forming reactions. Two strategies are given in the book using photoredox or electrochemical methods. The first strategy describes that the hydroalkylation of alkynes via photoredox-mediated Ni/Ir dual catalysis produces trisubstituted alkenes as versatile synthetic building blocks for the synthesis of pharmaceutical agents and natural products. High regioselectivity and E/Z-selectivity were achieved by introducing silyl groups that can provide steric and electronic effects to these selectivities with extensive opportunities for post-functionalization. The second strategy enables the development of C(sp3)-heteroatom bond-forming reactions through the electrochemical activation of C(sp3)-B bonds. The bonding of heteroatoms to carbon atoms has been an enduring subject of investigation for organic chemists. The function of most molecules is mainly determined by heteroatoms attached to the carbon atom, although the backbone structure of organic compounds comprises carbon fragments.

Organic Reaction Mechanisms 2020

Mark G Moloney

Organic Reaction Mechanisms 2020 , the 56th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2020. The following classes of organic reaction mechanisms are comprehensively An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation.

Handbook of Ionic Liquids: Fundamentals, Applications and Sustainability

Pardeep Singh, Sanchayita Rajkhowa, Anik Sen, Jyotirmoy Sarma

A one-stop reference for researchers interested in ionic liquids and their applications Handbook of Ionic Fundamentals, Applications, and Sustainability , constitutes an overview of the latest advances in ionic liquid chemistry. It offers a comprehensive summary of the development history of ionic liquids, their design, and the diverse array of applications―including green and sustainable synthesis, catalysis, drug development and medicine, biotechnology, materials science, and electrochemistry. The authors explain a variety of processes used to develop novel materials with ionic liquids and describe likely future developments using practical examples taken from contemporary research and development in the field. The book includes discussions of biomass conversion, CO 2 capture, and more. You’ll also Perfect for organic, catalytic, physical, analytical, and environmental chemists, Handbook of Ionic Fundamentals, Applications, and Sustainability will also benefit electrochemists, materials scientists, and biotechnologists with an interest in ionic liquids and their application.

Understanding Kinetic Resolution by Hydrolases: Maximizing Enantioselectivity

Abir B. Majumder, Kalluri V. S. Ranganath

This brief is a concise guide that explores the theory and practical aspects of improving enantioselectivity in enzymatic kinetic resolution, with a specific focus on the role of hydrolases in this process. Enzymatic kinetic resolution is a valuable technique for obtaining enantiopure compounds, and hydrolases are highlighted as a crucial class of enzymes widely used in industries for chiral synthesis involving kinetic resolution. The book emphasizes the importance of tuning and optimizing the enzymatic kinetic resolution process to achieve the highest possible enantiomeric excess in the final product or starting material while maintaining the desired yield. Through illustrative examples, the text aims to make the concept accessible and appealing to graduate students, researchers, and young organic chemists seeking to incorporate hydrolases in their stereoselective synthesis endeavors.