The book addresses the challenges in designing blockchain-based secured solutions for Industry 4.0 applications using artificial intelligence. It further provides a comparative analysis of various advanced security approaches such as edge computing, cybersecurity, and cloud computing in the realm of information technology. This The text aims to fill the gap between the theories of blockchain and its practical application in business, government, and defense among other areas. It further highlights the challenges associated with the use of blockchain for various industry 4.0 applications such as data analytics, software-defined networks, cyber-physical systems, drones, and cybersecurity. The text is primarily written for senior undergraduate, graduate students, and academic researchers in the fields of electrical engineering, electronics and communication engineering, computer engineering, manufacturing engineering, and industrial engineering.